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Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity

Fabien Lecaille , Thibault Chazeirat , Krzysztof K. Bojarski , Justine Renault , Ahlame Saidi , et al.
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020, 1868, pp.140318 -. ⟨10.1016/j.bbapap.2019.140318⟩
Journal articles hal-03489092v1

Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family

Nicolas Guyot , Herve Meudal , Sascha Trapp , Sophie Iochmann , Anne Silvestre , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩
Journal articles hal-03609429v1

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Eloïne Bestion , Zuzana Macek Jilkova , Jean-Louis Mège , Marie Novello , Keerthi Kurma , et al.
Therapeutic Advances in Chronic Disease, 2020, 11, pp.204062232094204. ⟨10.1177/2040622320942042⟩
Journal articles hal-03677273v1

Awake prone positioning of hypoxaemic patients with COVID-19: protocol for a randomised controlled open-label superiority meta-trial

Elsa Tavernier , Bairbre Mcnicholas , Ivan Pavlov , Oriol Roca , Yonatan Perez , et al.
BMJ Open, 2020, 10 (11), pp.e041520. ⟨10.1136/bmjopen-2020-041520⟩
Journal articles hal-03518800v1

Effect of Early Initiation of Varenicline on Smoking Cessation in COPD Patients Admitted for Exacerbation: The Save Randomized Clinical Trial

Raphael Le Mao , Cecile Tromeur , Nicolas Paleiron , Olivier Sanchez , Frédéric Gagnadoux , et al.
COPD: Journal of Chronic Obstructive Pulmonary Disease, 2020, 17 (1), pp.7-14. ⟨10.1080/15412555.2019.1703928⟩
Journal articles hal-02434544v1

Reducing Aerosol-Related Risk of Transmission in the Era of COVID-19: An Interim Guidance Endorsed by the International Society of Aerosols in Medicine

James Fink , Stephan Ehrmann , Jie Li , Patricia Dailey , Paul Mckiernan , et al.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2020, 33 (6), pp.300-304. ⟨10.1089/jamp.2020.1615⟩
Journal articles hal-03518819v1

The INHALE trial: multiple reasons for a negative result

Jean-Jacques Rouby , Antoine Monsel , Stephan Ehrmann , Adrien Bouglé , Pierre-François Laterre
The Lancet Infectious Diseases, 2020, 20 (7), pp.778-779. ⟨10.1016/S1473-3099(20)30481-3⟩
Journal articles hal-03518826v1

Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group

Jolyon Mitchell , Ariel Berlinski , Sebastian Canisius , David Cipolla , Myrna Dolovich , et al.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2020, 33 (4), pp.235-238. ⟨10.1089/jamp.2020.1622⟩
Journal articles hal-03518831v1

High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion

Jie Li , James Fink , Stephan Ehrmann
European Respiratory Journal, 2020, 55 (5), pp.2000892. ⟨10.1183/13993003.00892-2020⟩
Journal articles hal-03518836v1

Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 Transmission

Louis Bernard , Guillaume Desoubeaux , Elsa Bodier-Montagutelli , Jeoffrey Pardessus , Deborah Brea , et al.
Frontiers in Medicine, 2020, 7, 9 p. ⟨10.3389/fmed.2020.584036⟩
Journal articles hal-03036466v1

Scientific rationale for inhaled caspofungin to treat Pneumocystis pneumonia: A therapeutic innovation likely relevant to investigate in a near future…

Guillaume Desoubeaux , Adrien Lemaignen , Stephan Ehrmann
International Journal of Infectious Diseases, 2020, 95, pp.464-467. ⟨10.1016/j.ijid.2020.03.029⟩
Journal articles hal-03485390v1

Nebulization: A potential source of SARS-CoV-2 transmission

G. Reychler , L. Vecellio , J.C. Dubus
Respiratory Medicine and Research, 2020, 78, pp.100778. ⟨10.1016/j.resmer.2020.100778⟩
Journal articles hal-03150264v1

Pulmonary immune responses against SARS-CoV-2 infection: harmful or not?

Antoine Guillon , P. Hiemstra , Mustapha Si-Tahar
Intensive Care Medicine, 2020, 46 (10), pp.1897-1900. ⟨10.1007/s00134-020-06170-8⟩
Journal articles hal-03534523v1

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Eloïne Bestion , Zuzana Macek Jilkova , Jean-Louis Mège , Marie Novello , Keerthi Kurma , et al.
Therapeutic Advances in Chronic Disease, 2020, 11, pp.204062232094204. ⟨10.1177/2040622320942042⟩
Journal articles hal-02977880v1

Innovative preclinical models for pulmonary drug delivery research

Stephan Ehrmann , Otmar Schmid , Chantal Darquenne , Barbara Rothen-Rutishauser , Josue Sznitman , et al.
Expert Opinion on Drug Delivery, 2020, 17 (4), pp.463-478. ⟨10.1080/17425247.2020.1730807⟩
Journal articles hal-03518846v1

A consensus research agenda for optimising nasal drug delivery

Ben Forbes , Rene Bommer , Jonathan Goole , Marie Hellfritzsch , Wilbur de Kruijf , et al.
Expert Opinion on Drug Delivery, 2020, 17 (2), pp.127-132. ⟨10.1080/17425247.2020.1714589⟩
Journal articles hal-02566422v1

Pulmonary immune responses against SARS-CoV-2 infection: harmful or not?

Antoine Guillon , P. Hiemstra , Mustapha Si-Tahar
Intensive Care Medicine, 2020, 46 (10), pp.1897-1900. ⟨10.1007/s00134-020-06170-8⟩
Journal articles hal-03609413v1

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19

Pierre-François Dequin , Nicholas Heming , Ferhat Meziani , Gaëtan Plantefève , Guillaume Voiriot , et al.
JAMA Cardiology, 2020, 324 (13), pp.1298. ⟨10.1001/jama.2020.16761⟩
Journal articles hal-03863060v1

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

Gilles Lalmanach , Ahlame Saidi , Paul Bigot , Thibault Chazeirat , Fabien Lecaille , et al.
International Journal of Molecular Sciences, 2020, 21 (6), pp.1944. ⟨10.3390/ijms21061944⟩
Journal articles hal-03677271v1

High-Flow Aerosol-Dispersing versus Aerosol-Generating Procedures

Jie Li , Stephan Ehrmann
American Journal of Respiratory and Critical Care Medicine, 2020, 202 (8), pp.1069-1071. ⟨10.1164/rccm.202008-3317ED⟩
Journal articles hal-03518811v1

Reply to the reply to Scientific rationale for inhaled caspofungin to treat Pneumocystis pneumonia: A therapeutic innovation likely relevant to investigate in a near future …

Guillaume Desoubeaux , Adrien Lemaignen , Stephan Ehrmann
International Journal of Infectious Diseases, 2020, 95 (5), pp.469-470. ⟨10.1016/j.ijid.2020.04.006⟩
Journal articles hal-03485385v1

Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

Youenn Jouan , Antoine Guillon , Loïc Gonzalez , Yonatan Perez , Chloé Boisseau , et al.
Journal of Experimental Medicine, 2020, 217 (12), ⟨10.1084/jem.20200872⟩
Journal articles hal-03534519v1

Validation of Strasbourg environmental exposure chamber (EEC) ALYATEC ® in mite allergic subjects with asthma

Naji Khayath , Virginie Doyen , Alina Gherasim , Carmen Radu , Ibrahim Choual , et al.
Journal of Asthma, 2020, 57 (2), pp.140-148. ⟨10.1080/02770903.2018.1563902⟩
Journal articles hal-02566440v1

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

Gilles Lalmanach , Ahlame Saidi , Paul Bigot , Thibault Chazeirat , Fabien Lecaille , et al.
International Journal of Molecular Sciences, 2020, 21 (6), pp.1944. ⟨10.3390/ijms21061944⟩
Journal articles hal-02977886v1

Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice

Irene Lau , Carolina de Amat Herbozo , Meggie Kuypers , Qiaochu Lin , Christophe Paget , et al.
ImmunoHorizons , 2020, 4 (12), pp.797-808. ⟨10.4049/immunohorizons.2000100⟩
Journal articles hal-03365042v1

Bacterial Pneumonia in Brain-Dead Patients: Clinical Features and Impact on Lung Suitability for Donation*

Simon Poignant , Maxime Boutrot , Stephan Ehrmann , Francis Remerand , Jean-Christophe Venhard , et al.
Critical Care Medicine, 2020, 48 (12), pp.1760-1770. ⟨10.1097/CCM.0000000000004631⟩
Journal articles hal-03518804v1

High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion

Jie Li , James Fink , Stephan Ehrmann
European Respiratory Journal, 2020, 56 (4), pp.2003136. ⟨10.1183/13993003.03136-2020⟩
Journal articles hal-03518814v1

Oxidation of cathepsin S by major chemicals of cigarette smoke

Mylène Wartenberg , Pierre-Marie Andrault , Ahlame Saidi , Paul Bigot , Lydie Nadal-Desbarats , et al.
Free Radical Biology and Medicine, 2020, 150, pp.53 - 65. ⟨10.1016/j.freeradbiomed.2020.02.013⟩
Journal articles hal-03489853v1

Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice

Irene Lau , Carolina de Amat Herbozo , Meggie Kuypers , Qiaochu Lin , Christophe Paget , et al.
ImmunoHorizons , 2020, 4 (12), pp.797-808. ⟨10.4049/immunohorizons.2000100⟩
Journal articles hal-03534558v1

Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 Transmission

Louis Bernard , Guillaume Desoubeaux , Elsa Bodier-Montagutelli , Jeoffrey Pardessus , Deborah Brea , et al.
Frontiers in Medicine, 2020, 7, ⟨10.3389/fmed.2020.584036⟩
Journal articles hal-03609424v1